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Developer Sellar鈥檚 Paddington Cube proposals are to face a second High Court challenge just weeks after another bid to derail the project moved forward.

The 拢775m mixed-use scheme, designed for developer Sellar Group, won planning permission from Westminster council last year after being radically redesigned from original plans for a 72-storey tower to a squat 19-storey block.

Campaign group Save Britain鈥檚 Heritage last month secured a first-stage judicial review hearing into the legal soundness of communities secretary Sajid Javid鈥檚 decision not to call in the scheme for a planning inquiry, based on its size and the impact on nearby heritage assets, such as the grade I-listed Paddington station.

Now, Imperial College Healthcare NHS Trust, which runs the neighbouring St Mary鈥檚 Hospital, has launched a separate High Court challenge to Westminster council鈥檚 approval of the scheme, which would deliver 33,500sq m of offices, 7,500sq m of retail and restaurant space and a new Bakerloo line station.

Imperial鈥檚 challenge centres around safe access for ambulances to St Mary鈥檚 when the Paddington Cube is developed, on the site of an Edwardian sorting office between the hospital and the train station.

According to the court documents, the trust was unaware of the developer鈥檚 proposals for ambulance access at the time of the planning committee meeting that approved the scheme, and that those proposals had subsequently proved 鈥渦ndeliverable鈥� because they 鈥渁ssumed the relocation of facilities that could not be relocated鈥�.

A trust spokeswoman said: 鈥淲e have been continuing to engage with the council to seek amendments to the section 106 agreement to address our safety concerns.

鈥淏ut, as the deadline for applying to make a formal legal challenge was Monday September 25, we felt there was no alternative but to make an application in order to keep all options open.

鈥淲e are still hopeful that we can achieve amendments that address our safety concerns without further legal action.鈥�

Westminster City Council cabinet member for planning and public realm Cllr Daniel Astaire said: 鈥淪afety is of paramount importance in all of the council鈥檚 planning decisions.

鈥漈he developer has also given the hospital the option of funding, at the developer鈥檚 own cost, the hospital鈥檚 own preferred new road.

鈥淭he City Council, Transport for London, the Mayor for London and the Department for Communities and Local Government have considered all the issues raised but having undertaken transport surveys and assessments do not agree with the hospital鈥檚 stance on this matter. We await the outcome of the court proceedings.鈥�

A spokesperson for Sellar said: 鈥淭he access road which will be built to adoptable standards that forms part of the consented plans by the developer has been recognised by all public transport authorities as safe.

鈥淭he current access route is a disaster and those ambulances travelling virtually the full length of an extremely congested Praed Street down from Edgware Road already struggle to reach the hospital in good time.

鈥淥ur route avoids this dangerous Praed Street, London Street junction. 鈥淲e believe along with a number of independent experts that this new access road will be a safer and more efficient road.鈥�

A date has yet to be set for Imperial鈥檚 challenge to the Cube. In August, Save Britian鈥檚 Heritage said it expected its challenge to be heard before the end of the year.

Its review revolves around transparency and Javid鈥檚 failure to give a reason not to call in the scheme for an inquiry when the decision was announced in March.

Last month, Save director Henrietta Billings said the scale of the Cube 鈥� designed for Shard developer Sellar Property Group 鈥� was entirely alien to its immediate neighbouring buildings in a conservation area, and sent out a message that Westminster was abandoning its once-exemplary conservation and design policies.

鈥淭his challenge has potentially wide-reaching implications - it goes to the heart of transparent and accountable government decision,鈥� she said.

鈥淢inisterial decisions must stand up to robust scrutiny 鈥� the duty of government to give reasons for decisions is relevant to anyone involved with the planning system. We are pleased that this challenge will now proceed.鈥�